Research Use Only. Not for use in diagnostic tests.
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Epithalon - 40mg Vials
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Product Format
40mg vials
Vial Size
40mg
Vial Capacity
3 mL
Box Combinations
80mg, 200mg, 400mg
Cost per milligram
$1.98 – $2.70
Multi-vial Purity
99.86%
Endotoxin Screening
PASSED
Heavy Metals Screening
PASSED
Purity Screening
PASSED
Independently Tested
YES
Peptide Partners Manufacturer Id: WF03
Batch Id: ET202604
Research Studies
(for educational purposes only)
Epitalon Protects Against Post-Ovulatory Aging-Related Damage of Mouse Oocytes In Vitro
Authors: X. Yue, S. Liu, J. Guo, T. Meng, X. Zhang, H. Li, C. Song, Z. Wang
This in vitro study evaluated Epitalon, also known as Epithalon, in a mouse oocyte aging model. The researchers added Epitalon to the culture medium and assessed oocyte quality across 6, 12, and 24 hours of post-ovulatory aging. Epitalon treatment reduced intracellular reactive oxygen species, decreased spindle defects and abnormal cortical granule distribution, and increased mitochondrial membrane potential and mitochondrial DNA copy number. The authors reported that these effects were associated with reduced apoptosis during the in vitro aging window and suggested that Epitalon may delay oocyte aging through modulation of mitochondrial activity and oxidative stress.
Plain English Interpretation
This was a controlled laboratory study, not a human-use trial. In cultured mouse egg cells, Epithalon was associated with lower oxidative stress and better preservation of several cellular quality markers during aging outside the body. The main research takeaway is that Epithalon may interact with mitochondrial and oxidative-stress pathways in cell-culture conditions.
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis During Neurogenesis: Possible Epigenetic Mechanism
Authors: V. Khavinson, F. Diomede, E. Mironova, N. Linkova, S. Trofimova, O. Trubiani, S. Caputi, B. Sinjari
This study investigated AEDG peptide, identified as Epitalon/Epithalon, in human gingival mesenchymal stem cells. The researchers reported increased synthesis and mRNA expression of neurogenic differentiation markers including Nestin, GAP43, β Tubulin III, and Doublecortin. Molecular modeling suggested that AEDG may bind to histone H1 regions that interact with DNA, providing a proposed epigenetic mechanism for changes in neurogenesis-related gene expression and protein synthesis.
Plain English Interpretation
This cell-based study looked at how Epithalon may affect gene-expression programs tied to neuronal differentiation. The researchers observed increases in several markers commonly associated with early nerve-cell development and proposed that Epithalon may act partly through epigenetic interactions with chromatin-associated proteins. These findings are mechanistic and laboratory-based.
Peptide Regulation of Skin Fibroblast Functions During Their Aging In Vitro
Authors: N. Lin'kova, A. Drobintseva, O. Orlova, E. Kuznetsova, V. Polyakova, I. Kvetnoy, V. Khavinson
Publication: Bulletin of Experimental Biology and Medicine, 2016
This in vitro study examined several short peptides, including AEDG, in aging skin fibroblast cultures. The researchers assessed markers related to proliferation, regeneration, aging, apoptosis, and extracellular matrix remodeling. Across the studied peptides, the authors reported reduced MMP-9 synthesis, increased Ki-67 and CD98hc expression, and, for AED and AEDG, suppression of caspase-dependent apoptosis that increased during cell-culture aging.
Plain English Interpretation
This laboratory study tested how short peptides affected aging-related behavior in cultured skin fibroblast cells. AEDG, the tetrapeptide commonly referred to as Epithalon/Epitalon, was associated with changes in markers of cell proliferation, tissue-remodeling activity, and programmed cell-death signaling. The findings support Epithalon's use as a research compound for studying cellular aging pathways in vitro.
